Optimization of a Self-Microemulsifying Drug Delivery System for Oral Administration of the Lipophilic Drug, Resveratrol: Enhanced Intestinal Permeability in Rat

Purpose: This study aimed to formulate Resveratrol, a practically water-insoluble antioxidant in self-microemulsifying drug delivery system (SMEDDS) improve the solubility, release rate, and intestinal permeability of drug. Methods: The suitable oil, surfactant, co-surfactant were chosen according solubility study. Utilizing design experiment (DoE) method, pseudo-ternary phase diagram was plotted based on droplet size. In vitro dissolution single-pass perfusion performed for investigation in-situ drugs formulated as SMEDDS rat intestine using High-Performance Liquid Chromatography. Results: Castor Cremophor RH60, PEG 1500 selected co-surfactant. According diagram, nine formulations developed microemulsions with sizes ranging between 145-967 nm. Formulations passed centrifuge freeze-thaw stability tests. optimum formulation possessed an almost 2.5-fold higher cumulative percentage released resveratrol, comparison resveratrol aqueous suspension within 120 minutes. results suggested 2.6-fold than that suspension. Conclusions: can be considered oral observed increased permeability, which could consequently enhance bioavailability therapeutic efficacy